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Abstract Recovery‐based design links building‐level engineering and broader community resilience objectives. However, the relationship between above‐code engineering improvements and recovery performance is highly nonlinear and varies on a building‐ and site‐specific basis, presenting a challenge to both individual owners and code developers. In addition, downtime simulations are computationally expensive and hinder exploration of the full design space. In this paper, we present an optimization framework to identify optimal above‐code design improvements to achieve building‐specific recovery objectives. We supplement the optimization with a workflow to develop surrogate models that (i) rapidly estimate recovery performance under a range of user‐defined improvements, and (ii) enable complex and informative optimization techniques that can be repeated for different stakeholder priorities. We explore the implementation of the framework using a case study office building, with a 50th percentile baseline functional recovery time of 155 days at the 475‐year ground‐motion return period. To optimally achieve a target recovery time of 21 days, we find that nonstructural component enhancements are required, and that increasing structural strength (through increase of the importance factor) can be detrimental. However, for less ambitious target recovery times, we find that the use of larger importance factors eliminates the need for nonstructural component improvements. Such results demonstrate that the relative efficacy of a given recovery‐based design strategy will depend strongly on the design criteria set by the user. 

Abstract The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this article, we describe significant updates that we have made over the last two years to the resource. The number of sequences in UniProtKB has risen to approximately 190 million, despite continued work to reduce sequence redundancy at the proteome level. We have adopted new methods of assessing proteome completeness and quality. We continue to extract detailed annotations from the literature to add to reviewed entries and supplement these in unreviewed entries with annotations provided by automated systems such as the newly implemented Association-Rule-Based Annotator (ARBA). We have developed a credit-based publication submission interface to allow the community to contribute publications and annotations to UniProt entries. We describe how UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.